Digestive system diseases and disorders: such as abdominal distention, diarrhea or constipation, and so on.
Endocrine changes: some women are often in patients with menstrual period occurred, and may decline in estrogen-related.
The spirit of factors: Some patients in the spirit of tension, emotional volatility, the poor state of sleep where the disease may be related to autonomic dysfunction.
Genetic factors: If both parents are suffering from recurrent oral ulcers, about 80 of their children - 90% of illness, if breast cancer was one of the parents when their children about 50-60 per cent prevalence.
Other factors: a lack of trace elements such as zinc, iron, folic acid, vitamin B12, can reduce immune function, increased incidence of recurrent oral ulcers the possibility.