And now that the following factors related to the occurrence of gastric cancer:
(A) environmental factors: different countries and regions, the incidence of the significant difference between that and environmental factors, the most important factor is diet.
Salt may be Exogenous induced by one of the factors of gastric cancer. Residents intake of salt and more countries have a high incidence of gastric cancer, nitrosamine compounds have been successfully induced gastric cancer in animals, smoked fish contain more of the 34 - benzopyrene (benzopyrene), mouldy food containing more Mycotoxins; processed rice covered in talcum powder outside its chemical structure and nature of asbestos fibres are similar to the above material, are considered carcinogenic effect.
(B) genetic factors: some families in some of the higher incidence of gastric cancer, gastric cancer data show that occurred in the A blood group O blood type than the people who for more.
(C) immune factors: the lower the immune function of the higher incidence of gastric cancer, immune dysfunction may be the cancer of the immune supervisory role in the decline of gastric cancer in a certain sense.
(D) pre-cancerous change: the so-called pre-cancerous change is that some of the strong tendency of malignant lesions, such as lesions may not be addressed for the development of gastric cancer. Pre-cancerous changes including pre-cancerous condition (precancerous conditions) and pre-cancerous lesions (precancerous lesions).
1. Gastric pre-cancerous condition
(1) chronic atrophic gastritis: chronic atrophic gastritis and gastric cancer incidence was significantly positive correlation.
(2) pernicious anemia: pernicious anemia in patients with gastric cancer in 10 percent of gastric cancer incidence rate for the normal population of 5 to 10 times.
(3) gastric polyps: adenomatous polyps-or-villi of the stomach while the proportion of polyps is not high, the cancer rate of 15% to 40%, greater than 2 cm in diameter were higher rates of cancer, and proliferation of cancerous polyps多见Rate of only 1 percent.
(4) residual stomach: benign gastric residual disease after surgery in the stomach cancer that residual stomach. Stomach cancer after surgery especially in the beginning after 10 rate increased significantly.
(5) benign gastric ulcer: gastric ulcer is not in itself a pre-cancerous state, and the ulcer is prone to the edge of the mucous membrane and malignant intestinal metaplasia.
(6) of huge gastric folds (Menetrier disease): serum protein folds by the enormous loss of gastric mucosa, a clinical hypoproteinemia and swelling of about 10% of cancer.
2. Gastric pre-cancerous lesions
(1) profiled proliferation and inter-change: the former, also known as dysplasia, a chronic inflammation caused by the irreversible pathological cell proliferation, in a few cases can not be changed gastric cancer (anaplasia) are cancerous opportunities.
(2) IM: a type of small intestine and large intestine of two. Intestinal type (complete) with the characteristics of small intestinal differentiation, better, coliform (not complete) and the mucosa similar, can be divided into two subtypes: Ⅱ a can of non-sulfuric acid secretion of mucin; Ⅱ b-to Sulfuric acid secretion of this type of mucin close relationship with gastric cancer.